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检测细胞凋亡对于早期发现可能病变及评价疾病早期治疗效果具有重要意义。近年出现的许多基于MRI的新型凋亡探针改善了MR成像质量。通过合成针对细胞膜上外翻的磷脂酰丝氨酸和显示半胱氨酸天冬氨酸蛋白酶-3(Caspase-3)活性的尺寸更小的探针,提高了探针组织穿透力;为提高探针与靶点结合的特异性,优化了许多原有探针分子结构;基于MR成像新技术,合成了一些新型探针如Caspase-3敏感的纳米聚合性MR探针(C-SNAM),在一定程度上达到了提高信号强度的目的。
Detection of apoptosis for the early detection of possible lesions and evaluate the early treatment of disease is of great significance. In recent years, many new MRI-based apoptosis probes have improved MR imaging quality. Penetration of probe tissue is enhanced by the synthesis of phosphatidylserine that is ectopic to the cell membrane and a smaller probe that shows the activity of caspase-3; The specificity of the binding between the target and the target optimized many original probe molecular structures. Based on the new MR imaging technology, some novel probes such as Caspase-3-sensitive nano-polymerized MR probe (C-SNAM) To some extent, to achieve the purpose of increasing signal strength.