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目的观察３种常用的化学性肝毒剂对小鼠血清ＡＬＴ，Ｔｒｉｇ，ＬＤＬ等１１项生化指标的影响．方法取小鼠２０只，随机分为ＣＣｌ４中毒组和ＮＳ对照组，每组１０只．中毒组小鼠１５ｇ／ＬＣＣｌ４，１０ｍｇ／ｋｇ，ｉｇ，待中毒后２４ｈ，杀鼠取血，分离血清，由自动生化测定仪分别测定肝功能：ＡＬＴ，ＡＳＴ，总胆红素（ＢｉｌｉＴ）；血脂：三酰甘油（Ｔｒｉｇ）、胆固醇（Ｃｈｏｌ）、低密度脂蛋白（ＬＤＬ）、总蛋白（ＴＰ）、白蛋白（Ａｌｂ）；肝功能酶系：碱性磷酸酶（ＡＬＰ）、转肽酶（ＧＧＴ）和血糖（Ｇｌｕ）１１项生化指标．ＮＳ对照组同时给ＮＳ，ｉｇ．Ｄ半乳糖胺（ＤＧａｌ）：中毒鼠８００ｍｇ／ｋｇ，ｉｐ和ａ萘异硫氢酸酯（ＡＮＩＴ）：中毒鼠１００ｍｇ／ｋｇ，ｉｇ，动物分组，观察指标同ＣＣｌ４．结果ＣＣｌ４，ＤＧａｌ均能明显升高小鼠血中的ＡＬＴ，ＡＳＴ和ＬＤＬ水平，分别于中毒后２４ｈ达高峰．对ＢｉｌｉＴ，Ｔｒｉｇ，Ｃｈｏｌ，Ｇｌｕ，ＡＬＰ，ＧＧＴ，ＴＰ和Ａｌｂ无明显影响．ＡＮＩＴ对小鼠中毒后４８ｈ，血中ＡＬＴ，ＡＳＴ，ＢｉｌｉＴ，ＬＤＬ，ＡＬＰ和Ｃｈｏｌ水平明显升高，Ｔｒｉｇ明显降低，Ｇｌｕ略有下降；对ＧＧＴ，Ａｌｂ，ＴＰ无明显?
Objective To observe the effects of three commonly used chemical hepatotoxic agents on 11 biochemical indexes such as serum ALT, Trig and LDL in mice. Methods Twenty mice were randomly divided into CCl4 poisoning group and NS control group, with 10 mice in each group. Toxicity group mice 1 5g / LCCl4, 10mg / kg, ig, to be poisoned after 24h, killing rats to secrete blood serum were determined by automatic biochemical analyzer liver function: ALT, AST, total bilirubin (BiliT) , Triglyceride (Trig), cholesterol (Chol), low density lipoprotein (LDL), total protein (TP) and albumin (Alb); liver enzymes: alkaline phosphatase (ALP) Enzyme (GGT) and blood glucose (Glu) 11 biochemical indicators. NS control group to NS, ig. D galactosamine (D Gal): poisoning rats 800mg / kg, ip and a naphthalene isothiocyanate (ANIT): poisoning rats 100mg / kg, ig, animal groups, the same indicators with CCl4. Results CCl4, DGal can significantly increase the blood levels of ALT, AST and LDL, respectively, reached the peak at 24 h after poisoning. No significant effect on BiliT, Trig, Chol, Glu, ALP, GGT, TP and Alb. The levels of ALT, AST, BiliT, LDL, ALP and Chol in blood were significantly increased, Trig decreased significantly and Glu slightly decreased in ANIT mice 48h after poisoning, but no obvious changes in GGT, Alb and TP.