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目的观察绝经后妇女反复泌尿系感染应用小剂量雌激素预防的临床疗效及不良反应。方法将绝经期反复尿路感染患者随机分为两组,对照组(常规抗感染治疗)和观察组(加用雌激素预防治疗)。分别在治疗前、治疗结束时和结束后第2周、第6周进行尿常规和尿培养检查,以后每3个月随访1次,追踪随访1年。结果观察组有效率(91.2%)明显高于对照组(64.7%),两组比较差异有统计学意义(P<0.01),并且观察组的复发率也明显低于对照组,两组比较差异有统计学意义(P<0.01)。结论使用抗生素联合小剂量雌激素预防治疗绝经期妇女反复尿路感染比单纯使用抗生素治疗效果好,并可减少复发。
Objective To observe the clinical efficacy and adverse reactions of low dose estrogen prophylaxis in postmenopausal women with recurrent urinary tract infections. Methods The patients with recurrent urinary tract infection during menopause were randomly divided into two groups: control group (routine anti-infective treatment) and observation group (plus estrogen preventive treatment). Urine routine examination and urine culture examination were performed before treatment, at the end of treatment and at the end of the second week and the sixth week after the end of follow-up. The follow-up visits were conducted every 3 months and followed up for 1 year. Results The effective rate of the observation group (91.2%) was significantly higher than that of the control group (64.7%), the difference between the two groups was statistically significant (P <0.01), and the recurrence rate of the observation group was also significantly lower than that of the control group There was statistical significance (P <0.01). Conclusion The combination of antibiotics and low-dose estrogen for the prevention and treatment of recurrent urinary tract infections in postmenopausal women is better than antibiotics alone, and can reduce recurrence.