恶性组织细胞病(简称恶组,原名恶性网状细胞病)在我国并非很少见的疾病。其预后之恶劣与急性白血病相类似。多年来,治疗效果一直都很差。近年来,采用多种抗肿瘤药物的联合化疗以治疗造血系统及淋巴网状系统的恶性疾病有很多报导,且获得了较好的疗效。但对于恶性组织细胞病的化学疗法报导仍很少。近三年来,我们以 COP(环磷酰胺、新长春 Malignant histiocytosis (abbreviated as evil group, formerly known as malignant reticulocyte disease) is not a rare disease in our country. The bad prognosis is similar to acute leukemia. For many years, the treatment effect has been very poor. In recent years, a variety of anti-cancer drugs have been used in combination with chemotherapy to treat malignant diseases of the hematopoietic system and the lymphatic reticular system. Many reports have been reported and good results have been obtained. However, there are still few reports of chemotherapy for malignant histiocytosis. In the past three years, we have used COP (Cyclophosphamide, New Changchun)