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目的 :探讨血清乳酸脱氢酶 (LDH)及其同工酶 (LDHi)在慢性乙型肝炎 (CHB)中的变化和临床意义。方法 :测定 111例CHB患者 ,42例慢性乙型肝炎病毒携带者 (AsC)和 40例健康体检人血清LDH及LDHi。结果 :LDH5和LDH5 /LDH 4比值三组间差异非常显著 (P =0 .0 0 0 ) ,且CHB组 >AsC组 >对照组 (P均 <0 .0 5 )。在CHB组内 ,LDH5和LDH 5 /LDH 4比值随CHB组内分级的增高而增加 ,重度 >中度 >轻度 (P均 <0 .0 5 ) ;并LDH 5与AST、ALT、GGT、TBA、LDH这些指标有良好相关性 (P <0 .0 1)。结论 :LDH同工酶检测对判断CHB患者病情程度及监测AsC的健康状况是一个很好的指标
Objective: To investigate the changes and clinical significance of serum lactate dehydrogenase (LDH) and its isozymes (LDHi) in chronic hepatitis B (CHB). Methods: Serum LDH and LDHi were measured in 111 patients with CHB, 42 patients with chronic hepatitis B virus (AsC) and 40 healthy people. Results: The differences between LDH5 and LDH5 / LDH4 ratios were significant (P = 0.000), and CHB group> AsC group> control group (all P <0.05). In CHB group, the ratio of LDH5 and LDH 5 / LDH 4 increased with the increase of grading in CHB group, with severe> moderate> mild (P <0.05), and LDH 5 with AST, ALT, GGT, TBA, LDH these indicators have a good correlation (P <0. 01). Conclusion: The detection of LDH isoenzyme is a good indicator for judging the severity of CHB and monitoring the health status of AsC