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目的:探讨左旋咪唑治疗慢性咽炎的远期疗效。方法:收集2001年3月～2009年12月我科门诊治疗的128例有效回访的慢性咽炎患者,随机分为对照组和试验组,对照组在采用常规的包括戒除烟酒,消除鼻部、鼻咽部或扁桃体炎症的基础上,局部含服溶菌酶片。治疗组在常规病因治疗基础上,用左旋咪唑片饭后顿服,每公斤体重25mg,每周连服2天,疼痛较剧可2天后加服1天,3～6月为1疗程。一年后随访,全部病例获得1～4年的随访。结果:对照组:显效13例(19%)有效34例(49%)无效23例(33%)总有效率67%。其中1年内无复发5例(7%),2年内无复发1例(1.5%),3年内无复发0例(0%)。试验组:显效37例(64%)有效17例(29%)无效4例(7%)总有效率(93%)。其中1年内无复发30例(52%),2年内无复发23例(40%),3年内无复发10例(17%),4年内无复发9例(16%)。两组疗效差异有统计学意义(P<0.05)。结论:左旋咪唑能够使慢性咽炎的症状明显减轻,发作次数减少,对慢性咽炎的远期治疗有重要价值。
Objective: To investigate the long-term efficacy of levamisole in the treatment of chronic pharyngitis. Methods: A total of 128 patients with chronic pharyngitis who returned from our hospital from March 2001 to December 2009 were collected and randomly divided into control group and experimental group. Patients in control group were treated with routine alcohol and tobacco abstinence, Nasopharyngeal or tonsil inflammation, based on the local containing lysozyme tablets. The treatment group on the basis of conventional etiology, with levamisole meal Dayton clothing, body weight 25mg per kilogram per day with clothes for 2 days, the pain can be more than 2 days after the service plus 1 day, 3 to 6 months for a course of treatment. Follow-up one year later, all cases were followed up for 1 to 4 years. Results: In the control group, 13 cases (19%) were effective and 34 cases (49%) were ineffective. The total effective rate was 67% in 23 cases (33%). There was no recurrence in 5 cases (7%) in 1 year, no recurrence in 2 years (1.5%) and no recurrence in 0 (0%) in 3 years. The experimental group: 37 cases (64%) effective in 17 cases (29%) ineffective in 4 cases (7%) the total effective rate (93%). Among them, there were no recurrence in 30 cases (52%) in one year, no recurrence in 23 cases (40%) in 2 years, no recurrence in 10 years (17%) in 3 years and no recurrence in 9 years (16%). The difference between the two groups was statistically significant (P <0.05). Conclusion: Levamisole can alleviate the symptoms of chronic pharyngitis and reduce the number of attacks, which is of great value to the long-term treatment of chronic pharyngitis.