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【目的】探讨使用不同容量臭氧治疗椎间盘源性下腰痛患者的疗效。【方法】选取2013年8月至2014年8月本院住院的下腰痛患者作为研究对象，按纳入及排除标准，共103例进入本研究，并按照椎间盘造影显示造影剂流入的范围结果将患者分为三组：A组（造影剂流入外层纤维环）计33例，B组（造影剂流出至纤维环外层）计34例，C组（造影剂流出至硬膜外隙）计36例，每组患者随机注入5～20 m L臭氧，比较各组患者注入不同容量臭氧后的疗效。【结果】各分组中注入10 m L、15 m L、20 m L间行组内疗效比较，其有效率相比较差异无显著性（P ＞0．05），但注入10～20mL组其有效率远高于注入5mL者，且差异有显著性（P＜0．05）。【结论】对于各种损伤程度的椎间盘而言，选择注入10～20 m L的臭氧量均是有效的注射剂量，且对于椎间盘造影2级者，注入10 m L臭氧可取得最佳的显效率且较不易损伤纤维环诱发腰部或下肢疼痛，对于椎间盘造影3级者注射15 m L臭氧同样可达到最佳显效率。“,”[Objective] To explore the efficacies by using different capacities of ozone in patients with dis‐cogenic low back pain (DLBP) .[Methods] From August 2013 to August 2014 at our hospital ,a total of 103 eligible DLBP patients were recruited and divided into three groups according to the results of discography . That is ,group A (flow of contrast medium into outer annulus fibrosus) ,group B (flow of contrast medium flows out of outer annulus fibrosus) ,group C (flow of contrast medium into epidural space) .And 5~20 ml o‐zone was randomly injected into each patient .The efficacies of each group were compared .[Results] When 5 ml was compared with 10 ,15 ,20 ml in each group ,there were statistically significant differences in efficacy ( P >0 .05) .When 10 ,15 ,20 ml were compared ,no statistically significant differences existed in efficacy ( P <0 .05) .And the efficacies of 10~20 ml ozone were much higher than those of 5 ml .[Conclusion] For various degrees of disc damage ,an injection dose of 10~20 ml ozone is effective .For group B ,an injection of 10 ml ozone may achieve the best efficacy and reduce damage to annulus so as to avoid inducing waist or leg pain .For group C ,an injection of 15 ml ozone is similarly effective .