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采用放射免疫法（ＲＩＡ）测定了活血抗纤复方对日本血吸虫性早期肝纤维化小白鼠体内血清中Ⅰ，Ⅲ型前胶原（ＰｒｏｃｏｌｅｇｅｎＴｙｐｅⅠ和ＰｒｏｃｏｌｅｇｅｎＴｙｐｅⅢ）的作用。结果表明：活血抗纤复方具有明显的降解ＰＣ－Ⅲ型纤维的作用，可以使胶原纤维明显减少，血清ＰＣ－Ⅲ含量显著下降（Ｐ＜０．００１）；血清ＰＣ－Ⅰ型前胶原有所下降，但与对照组比较，无显著差异（Ｐ＞０．０５）。说明中药能有效地抑制实验动物血清中ＰＣ－Ⅰ型前胶原含量增加（Ｐ＜０．０５），但不能抑制血清中ＰＣ－Ⅲ型增加（Ｐ＞０．０５）。提示活血抗纤复方（桃仁水蛭煎剂）能有效地促进实验性肝纤维化的吸收与分解，具有临床应用价值。
Radioimmunoassay (RIA) was used to determine the effects of Huoxue Kangxian compound on type I and type III procollagen (Procolegen Type I and Procolegen Type III) in serum of mice with early hepatic fibrosis in Schistosoma japonicum. The results showed that: Huoxue Fangxian compound has obvious effects on degradation of PC-III fibers, which can significantly reduce the collagen fibers, serum PC-III content was significantly reduced (P <0.001); serum PC-I procollagen have some However, there was no significant difference compared with the control group (P>0.05). It shows that traditional Chinese medicine can effectively inhibit the increase of PC-I procollagen in serum of experimental animals (P<0.05), but it can not inhibit the increase of PC-III in serum (P>0.05). Tips Huoxue anti-fibrosis compound (Peach kernel Shuizhi decoction) can effectively promote the absorption and decomposition of experimental liver fibrosis, with clinical application value.