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目的分析在剖宫产手术中预防性地使用抗菌药物的时机。方法对2012年1月-2013年12月在海西州人民医院产科行剖宫产的490例产妇的临床资料进行回顾性分析。将2012年1-12月我院实行抗菌药物专项整治工作前收治的210例产妇纳入Ⅰ组,将2013年1-12月我院实行抗菌药物专项整治工作后收治的280例产妇纳入Ⅱ组。在为Ⅰ组产妇行剖宫产手术断脐后不为其使用抗菌药物,在其回到病房后为其应用头孢唑啉进行治疗,在为Ⅱ组产妇行剖宫产手术断脐后立即为其应用头孢唑啉进行治疗,并对比分析两组产妇在术后体温的变化、退热的时间及子宫内膜炎、切口感染的发生率。结果与I组产妇相比,Ⅱ组产妇的平均用药天数较短,感染率较低,差异显著(p<0.05),有统计学意义。结论严格遵循抗菌药物的使用原则,掌握正确的用药时机为剖宫产产妇进行预防性抗感染治疗,并缩短用药的时间可显著减少其发生细菌耐药的几率,缩短其住院的天数,减轻其经济负担,此法值得在临床上推广应用。
Objective To analyze the timing of prophylactic use of antimicrobials during cesarean section. Methods A retrospective analysis was performed on the clinical data of 490 mothers with cesarean section in the Hercynian People’s Hospital during January 2012 to December 2013. A total of 210 maternal women admitted to our hospital from January to December in 2012 were enrolled in group Ⅰ and 280 maternal women admitted to our hospital from January to December in 2013 were enrolled in group Ⅱ. In the first group of maternal cesarean section after the umbilical cord is not used for antimicrobial drugs, after its return to the ward for the application of cefazolin treatment, in the group Ⅱ maternal cesarean section after the umbilical cord immediately The application of cefazolin treatment, and comparative analysis of two groups of postpartum body temperature changes, fever and endometritis, incision infection incidence. Results Compared with the I group, the average number of days in the second group was shorter, the infection rate was lower, the difference was significant (p <0.05), with statistical significance. Conclusions Strictly follow the principle of using antimicrobial drugs, to master the correct timing of medication for prophylactic anti-infective treatment of cesarean section maternal and shorten the time of medication can significantly reduce the probability of bacterial resistance and shorten the length of hospital stay, Economic burden, this method is worth promoting in clinical application.