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目的探讨饮水高氟对儿童甲状腺功能的影响。方法选择高氟饮水地区和对照地区作为调查点,以当地出生成长的8～12岁儿童作为调查对象;氟离子选择电极法测定尿氟含量,砷铈催化分光光度法测定尿碘含量。按照《GB16004-1995》中甲状腺肿大的诊断标准诊断甲状腺肿大情况,应用放射免疫分析法测定血清中游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)和促甲状腺激素(TSH)三种激素水平。结果高氟区儿童尿氟含量为2.09 mg/L,对照区儿童尿氟含量为0.83mg/L,两者差异有统计学意义(p<0.05);高氟区儿童尿碘含量为294.85 mg/L,对照区儿童尿碘含量为468.82 mg/L,两者差异有统计学意义(P<0.05);高氟区儿童血清FT3的浓度为5.73 pmol/L,对照区儿童血清FT 3的浓度为4.60 pmol/L,两者差异有统计学意义(P<0.05);高氟区儿童血清FT4的浓度为7.40 pmol/L,对照区儿童血清FT4的浓度为8.07 pmol/L,两者差异无统计学意义(p>0.05);高氟区儿童血清TSH的浓度为1.03 pmol/L,对照区儿童血清TSH的浓度为1.10 pmol/L,两者差异无统计学意义(p>0.05);高氟区和对照区儿童甲状腺肿大差异无统计学意义(p>0.05)。结论饮水高氟可影响儿童血清FT3水平。
Objective To investigate the effect of drinking high fluoride on thyroid function in children. Methods High-fluoride drinking water areas and control areas were selected as the investigation points, and the children aged 8 to 12 years old who grew up in the local area were surveyed. Urinary fluoride content was determined by fluoride ion selective electrode method and urinary iodine content by arsenic and cerium catalytic spectrophotometry. Thyroid enlargement was diagnosed according to the diagnostic criteria of goiter in “GB16004-1995”. Radioimmunoassay was used to determine the levels of free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone TSH) three hormone levels. Results The urinary fluoride content was 2.09 mg / L in high fluoride area and 0.83 mg / L in control area, the difference was statistically significant (p <0.05). The urinary iodine content in children with high fluoride area was 294.85 mg / L, the urinary iodine content was 468.82 mg / L in children in the control area, the difference was statistically significant (P <0.05); the concentration of FT3 in children with high fluoride was 5.73 pmol / L, the concentration of FT 3 in control children was 4.60 pmol / L, the difference was statistically significant (P <0.05). The concentration of serum FT4 in children with high fluoride was 7.40 pmol / L and the concentration of FT4 in children with control was 8.07 pmol / L (P> 0.05). The concentration of serum TSH in children with high fluoride was 1.03 pmol / L and the concentration of TSH in control children was 1.10 pmol / L (p> 0.05). High fluoride There was no significant difference between the control group and the control group (p> 0.05). Conclusion High fluoride in drinking water can affect serum FT3 level in children.