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目的观察人脑胶质瘤组织中MMP-7和整合素αvβ5的表达,并探讨其可能的临床意义。方法采用免疫组织化学S-P法,检测38例不同病理分级脑胶质瘤和13例正常脑组织中MMP-7和整合素αvβ5的表达情况,探讨二者表达的相关性。结果 MMP-7和整合素αvβ5在脑胶质瘤中阳性表达均高于正常脑组织(P<0.01)。MMP-7蛋白表达水平与脑胶质瘤病理分级正相关(r=0.426,P<0.01);整合素αvβ5蛋白表达与病理分级正相关(r=0.323,P<0.05)。人脑胶质瘤中MMP-7的表达水平与整合素αvβ5的表达水平正相关(r=0.578,P<0.01)。结论 MMP-7和整合素αvβ5表达水平的测定可能有助于早期识别具有高度恶性的人脑胶质瘤并判断其预后。
Objective To observe the expression of MMP-7 and integrin αvβ5 in human glioma and to explore its possible clinical significance. Methods Immunohistochemical S-P method was used to detect the expression of MMP-7 and integrin αvβ5 in 38 gliomas of different pathological grades and 13 normal brain tissues, and to explore the correlation between them. Results The positive expressions of MMP-7 and integrin αvβ5 in gliomas were significantly higher than those in normal brain tissues (P <0.01). The expression of MMP-7 was positively correlated with the pathological grade of glioma (r = 0.426, P <0.01). The expression of integrin αvβ5 was positively correlated with the pathological grade (r = 0.323, P <0.05). The expression of MMP-7 in human glioma was positively correlated with the expression of integrin αvβ5 (r = 0.578, P <0.01). Conclusion The determination of the expression of MMP-7 and integrin αvβ5 may help to identify and judge the prognosis of human gliomas with high malignancy.