论文部分内容阅读
目的探究血清中胱抑素C(Cys-C)与老年冠心病冠脉病变程度的相关性。方法:冠心病患者作为观察组,非冠心病患者作对照组,测定所有入选者的血清Cys-C水平,冠状动脉造影采用Gensin积分对冠状动脉病变程度进行评介。结果观察组各亚组的血清Cys-C水平比较对照组高(P<0.05),多支冠脉病变组与对照组有统计学显著差异(P<0.01),冠心病各亚组间进行分析,双支冠脉病变组Cys-C与单支冠脉病变组比较有统计学差异(P<0.05),多支冠脉病变组与单支冠脉病变组组比较有统计学显著差异(P<0.05),Spearman相关性分析显示血清Cys-C水平与Gensin积分呈正相关(R=0.257,P<0.05)。结论血清Cys-C水平和冠心病冠脉病变程度呈正相关性(R=0.257,P<0.05),冠心病病变程度越高,Cys-C含量越高,检测血清Cys-C对评估冠心病冠脉病变程度有帮助,为冠心病的风险预测,危险分层、治疗提供一条新的线索和途径。
Objective To investigate the relationship between serum cystatin C (Cys-C) and coronary artery disease in elderly patients. Methods: The coronary heart disease patients were taken as the observation group and non-coronary heart disease patients as the control group. The serum Cys-C levels of all the patients were determined. The degree of coronary artery lesion was evaluated by Gensin integration. Results The levels of Cys-C in each subgroup of the observation group were significantly higher than those in the control group (P <0.05). There was a statistically significant difference between the multi-branched coronary artery group and the control group (P <0.01) (P <0.05). There was significant difference between CVI group and single coronary artery disease group (P <0.05). P <0.05). Spearman correlation analysis showed that serum Cys-C level was positively correlated with Gensin score (R = 0.257, P <0.05). Conclusions The level of serum Cys-C is positively correlated with the degree of coronary artery disease (R = 0.257, P <0.05). The higher the severity of coronary heart disease is, the higher the level of Cys-C is. It is helpful to predict the severity of coronary artery disease and provide a new clue and approach for the risk stratification and treatment of coronary heart disease.