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致敏前后灌胃给药(d1～d5,d11～d17)齐墩果酸(OA)对 Arthus 反应无明显影响攻击前48,24,1小时给药则有显著抑制作用,对可逆性被动 Arthus 反应有明显抑制作用,且显著抑制白细胞游走反应。OA 能显著稳定红细胞膜,抑制制霉菌素引起的足肿胀减少其炎症渗出物中酸性磷酸酶含量。OA 明显抑制 PGE、组织胺、LTB_4、激肽的合成或释施 PGE_2、组织胺、5-HT 和激肽的致炎作用,明显减少酒精中毒小鼠肝组织中丙二醛(MDA)含量提高小鼠肝组织中过氧化氢酶(CAT)活性,但对大鼠血清中超氧化物歧化酶(SOD)活性无明显影响。对 Arthus 反应大鼠血清中免疫复合物含量,巨噬细胞清除免疫复合物,单核-巨噬细胞系统吞噬功能及对总补体活性均无明显影响。
Oral administration before and after sensitization (d1 ~ d5, d11 ~ d17) oleanolic acid (OA) had no significant effect on Arthus reaction 48, 24 and 1 hour before challenge, there was a significant inhibitory effect on reversible passive Arthus Reaction was significantly inhibited, and significantly inhibited the leukocyte migration reaction. OA can significantly stabilize the erythrocyte membrane, inhibit the foot swelling caused by nystatin and reduce its inflammatory exudate acid phosphatase content. OA significantly inhibited the PGE, histamine, LTB_4, kinin synthesis or release of PGE_2, histamine, 5-HT and kinin induced inflammatory effects, significantly reduce the alcoholic mice liver malondialdehyde (MDA) content increased The activity of catalase (CAT) in the liver of mice had no significant effect on the activity of superoxide dismutase (SOD) in rat serum. There was no significant effect of Arthus reaction on serum immune complexes, macrophage immune complexes, monocyte-macrophage system phagocytosis and total complement activity.