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目的观察康莱特联合吉西他滨、顺铂(GP方案)治疗晚期非小细胞肺癌的疗效。方法选取西安市兵器工业五二一医院2010年1月—2013年1月收治的62例晚期非小细胞肺癌住院患者,随机分为观察组和对照组,各31例。观察组采用康莱特联合GP方案治疗,对照组单用GP方案治疗,比较两组的临床疗效。结果观察组总有效率高于对照组,KPS评分有效率高于对照组,差异均有统计学意义(P<0.05)。观察组患者白细胞计数减少4例,恶心、呕吐4例,腹泻5例,肝功能损害1例,肾毒性1例,少于对照组的8、7、6、3、2例,差异有统计学意义(P<0.05)。结论康莱特联合GP方案治疗晚期非小细胞肺癌优于单纯使用GP方案,提示康莱特有抗肿瘤作用。
Objective To observe the effect of Kanglaite combined with gemcitabine and cisplatin (GP regimen) in the treatment of advanced non-small cell lung cancer. Methods Sixty-two inpatients with advanced non-small cell lung cancer admitted to the May 21 Hospital of Xi’an Weaponry from January 2010 to January 2013 were randomly divided into observation group and control group, with 31 cases in each group. The observation group was treated with KLT combined with GP regimen, while the control group with GP regimen alone. The clinical efficacy was compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group, and the effective rate of KPS score was higher than that of the control group (P <0.05). In the observation group, there were 4 cases with decreased white blood cell count, 4 cases with nausea and vomiting, 5 cases with diarrhea, 1 case with liver dysfunction, 1 case with nephrotoxicity, less than 8, 7, 6, 3 and 2 cases in the control group Significance (P <0.05). Conclusion Kanglaite combined with GP regimen in the treatment of advanced non-small cell lung cancer is superior to the simple use of GP regimen, suggesting Kanglaite antitumor effect.