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前列腺素(PG)的研究进展很快。尤其是血栓素A_2(TXA_2)和前列环素(PGI_2)的发现,使血小板聚集机理和许多疾病发病机理的研究在分子水平上有了新的进展,提出了新的概念,大大促进了防治冠心病、高血压和脑血管意外等心血管疾病的临床和基础的研究。人类PG的前体为花生四烯酸(AA),当细胞膜受到生理、病理、化学或物理刺激时,通过磷脂酶A的作用释放出AA,后者在环氧酶的催化下,首先生成不稳定的PG内过氧化物(PGH_2),随即经TXA_2合成酶生
Prostaglandin (PG) research is progressing rapidly. In particular, the discovery of thromboxane A 2 (TXA 2) and prostacyclin (PGI 2) has led to new advances in the study of the mechanism of platelet aggregation and the pathogenesis of many diseases at the molecular level, has proposed new concepts and greatly promoted the prevention and treatment of coronary heart disease Heart disease, hypertension and cerebrovascular accident and other cardiovascular diseases, clinical and basic research. The precursors of human PG are arachidonic acid (AA), which is released by the action of phospholipase A when the cell membrane is physiologically, pathologically, chemically or physically stimulated, and the latter is first produced under the catalysis of cyclooxygenase Stable PG peroxide (PGH_2), followed by TXA_2 synthase