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以25％及50％沙棘油栓药液局部皮肤用药,对小白鼠巴豆油致耳部炎症、大白鼠角叉菜致足跖炎症皆有明显的抑制作用。沙棘油栓以120mg/只,240mg/只及480mg/只三个剂量,分组每天给家兔阴道用药,连续30d,对兔行为活动、食量、大小便、体重、肝功(SGPT)、肾功(血清尿素氮)、血象(血红蛋白、红细胞、白细胞及其分类)等皆无明显影响。兔的心、肝、脾、肺、肾、肾上腺、胸腺、子宫、阴道粘膜等器官组织肉眼观察和病理切片检查,均未发现明显的药物损害性病变。与对照组兔比较,皆无明显差异。沙棘油栓对豚鼠皮肤重复用药,未发现皮肤过敏性反应。
The topical application of 25% and 50% sea buckthorn oil suppository liquid had significant inhibitory effects on the ear inflammation caused by croton oil in rats and the inflammation of the paws caused by carrageenan in rats. Seabuckthorn oil plugs were divided into groups of 120mg/body, 240mg/only and 480mg/three doses for vaginal administration of rabbits for 30 days in a row. Behavioral activities, food intake, urine, weight, liver function (SGPT), and renal function were measured. (Blood serum urea nitrogen), blood (hemoglobin, red blood cells, white blood cells, and their classification) did not have any significant effect. The naked eye, liver, spleen, lung, kidney, adrenal gland, thymus, uterus, vaginal mucosa, and other organ tissues of rabbits were observed by naked eye and pathological biopsy. No obvious drug-damaged lesions were found. Compared with the control rabbits, there were no significant differences. Seabuckthorn oil plug was repeatedly used on guinea pig skin and no skin allergic reaction was found.