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本文介绍用中效原理分析化疗体外药敏试验联合用药效应的一种新方法。与其它方法相比,它所需的试验次数较少,不但能确定两种药物是否协同,而且能动态分析药物剂量变化时联合效应的变化情况,为化疗个体化治疗方案的制定提供定量分析的方法。本文给出两种药物联合应用效应分析的电脑程序,并对 CDDP、VCR 和5FU 对 LC-16细胞株的联合应用进行效应分析。
This article describes a new method to analyze the effect of combined drug use in vitro drug susceptibility testing using the principle of intermediate effect. Compared with other methods, it requires fewer trials. It not only can determine whether the two drugs are synergistic, but also can dynamically analyze the changes of combined effects when the drug dose changes, providing quantitative analysis of individualized chemotherapy treatment plan. method. This paper presents a computer program that combines the effects of the two drugs and analyzes the effects of combined use of CDDP, VCR, and 5FU on LC-16 cell lines.