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目的：观察5%咪喹莫特软膏治疗传染性软疣的临床疗效及安全性。方法选取2014年5~10月门诊确诊的传染性软疣患者90例，随机分为治疗组和对照组各45例。治疗组予5%咪喹莫特软膏治疗，对照组予重组人干扰素α-2b乳膏治疗并加用他扎罗汀凝胶。2组治疗期间均每周复诊1次，连续观察4周，疗程结束时判定疗效。结果治疗组第1、2、3、4周有效率均优于对照组，差异有统计学意义（ P<0.05）。结论5%咪喹莫特乳膏治疗传染性软疣，疗效确切，不良反应小，安全性高，值得临床推广应用。“,”Objective To observe the clinical efficacy and safety of 5% imiquimod cream in the treatment of mollus-cumcontagiosum. Methods 90 cases of molluscumcontagiosum patients,were randomly divided into treatment group and con-trol group,45 cases in each. The treatment group treated with 5% imiquimod cream,The control group treated with recombinant human interferon alpha 2b cream and tazarotene gel. The 2 groups were reviewed 1 times a week,for 4 weeks,the efficacy was determined at the end of the course. Results The effective rate of 1st,2nd,3rd and 4thweeks in the treatment group were bet-ter than those in the control group,the difference was statistically significant(P<0. 05). Conclusion The clinical effect of 5% Imiquimod Cream treating molluscumcontagiosum,less adverse reaction,high safety. Worthy of clinical popularization and application.