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目的观察叶酸干预治疗对H型高血压患者Hcy水平和主要心血管事件的影响。方法选择我院2009年3月-2010年3月所收治的216例H型高血压患者,随机分为两组,对照组108例患者采用常规健康教育及降压治疗,观察组108例患者在对照组基础上加用叶酸干预治疗,疗程结果后所有患者均随访3-24个月,观察治疗前后两组患者Hcy水平变化及患者主要心血管事件发生率。结果两组患者治疗前Hcy水平比较差异无显著性,治疗后观察组Hcy水平明显下降,与治疗前与对照组比较差异具有显著性,随访3-24个月,观察组共发生心血管事件6例,分别为脑卒中3例,心肌梗塞3例,发生率为5.56%;对照组共发生17例,分别为心血管病死亡2例,脑卒中8例,心肌梗塞7例,发生率为15.74%,明显高于观察组,两组比较差异具有显著性,有统计学意义P<0.05。结论 H型高血压患者仅针对降压治疗不能达到预期的效果,采用叶酸干预治疗可调节患者Hcy水平,从而减少心血管事件的发生率。
Objective To observe the effect of folic acid intervention on Hcy level and major cardiovascular events in patients with Hypertension. Methods A total of 216 H-type hypertensive patients admitted to our hospital from March 2009 to March 2010 were randomly divided into two groups. The control group of 108 patients received routine health education and antihypertensive treatment. The observation group of 108 patients Control group based on the use of folic acid intervention, the treatment outcome of all patients were followed up for 3-24 months, before and after treatment to observe changes in Hcy levels and patients with major cardiovascular events. Results There was no significant difference in the level of Hcy between the two groups before treatment. The level of Hcy in the observation group decreased significantly after treatment, which was significantly different from that of the control group before treatment. After 3-24 months of follow-up, cardiovascular events 6 Cases were 3 cases of stroke, 3 cases of myocardial infarction, the incidence was 5.56%; control group, a total of 17 cases were cardiovascular deaths in 2 cases, stroke in 8 cases, myocardial infarction in 7 cases, the incidence was 15.74 %, Significantly higher than the observation group, the difference was significant between the two groups, with statistical significance P <0.05. Conclusions Hypertension patients can not achieve the expected effect only by antihypertensive treatment. The treatment of folic acid can regulate the Hcy level of patients and thus reduce the incidence of cardiovascular events.