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目的:评价伊曲康唑与支气管肺灌洗疗法联用对肺部多重耐药菌感染患者的临床疗效。方法:选取2014年1月—2015年2月期间收治的肺部多重耐药菌感染患者94例,将其按照治疗方案的不同将其分为观察组(n=47例)和对照组(n=47例);对照组患者均给予伊曲康唑治疗,观察组在对照组治疗基础上采用支气管肺灌洗疗法治疗,评价两组患者治疗后的总有效率和血氧分压、每日平均痰液量和呼吸频率的改善情况。结果:观察组患者治疗后血氧分压、呼吸频率和每日平均痰量分别为(12.89±0.75)k Pa、(18.72±1.82)次/min和(18.61±4.52)m L/d和治疗的总有效率为97.87%均优于对照组为(7.53±0.26)k Pa、(35.61±3.69)次/min和(132.64±12.13)m L/d和治疗的总有效率为68.08%(P<0.05)。结论:采用伊曲康唑与支气管肺灌洗疗法联用治疗肺部多重耐药菌感染患者的临床疗效优于单用伊曲康唑的疗效,可有效改善患者呼吸、痰液量和血氧分压指标。
Objective: To evaluate the clinical efficacy of itraconazole combined with bronchoalveolar lavage in patients with multi-drug resistant pulmonary infection. Methods: Ninety-four patients with multi-drug resistant pulmonary infection were selected from January 2014 to February 2015. The patients were divided into observation group (n = 47) and control group (n = 47 cases). Patients in the control group were treated with itraconazole. The observation group was treated with bronchoalveolar lavage therapy on the basis of the control group, and the total effective rate and partial pressure of oxygen after treatment were evaluated. The daily Average sputum volume and respiratory rate improvement. Results: After treatment, the partial pressure of oxygen, respiratory rate and average daily sputum volume in the observation group were (12.89 ± 0.75) kPa, (18.72 ± 1.82) / min and (18.61 ± 4.52) m L / d, respectively (7.57 ± 0.26) kPa, (35.61 ± 3.69) / min and (132.64 ± 12.13) m L / d respectively) and the total effective rate was 68.08% (P <0.05). Conclusion: The clinical efficacy of itraconazole in combination with bronchoalveolar lavage in the treatment of patients with multiple drug-resistant lung infections is better than that of itraconazole alone, which can effectively improve the respiratory, sputum and oxygen Partial pressure indicator.