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本文就合并与未合并原发性肝癌的肝硬化的血清氨基酸浓度(血清氨基图)进行探讨。合并肝癌21例,未合并者19例。与正常对照组比较,合并肝癌者血清氨基酸浓度低(P<0.02),未合并肝癌者则否。鼠经乙硫氨酸诱发肝癌后,其血清氨基图与肝癌患者相似。一般肝癌组织中的氨基酸较非癌结节中的增多,提示肿瘤细胞内氨基酸池增大。肝癌病人肿瘤细胞内蛋白合成亢进,而使血清中的多种氨基酸,首先是蛋氨酸、苯丙氨酸及苏氨酸等主要氨基酸消耗而
This article discusses serum amino acid concentrations (serum aminograms) of liver cirrhosis with and without primary liver cancer. There were 21 cases with liver cancer, and 19 cases without merger. Compared with the normal control group, serum amino acid concentrations in patients with liver cancer were low (P < 0.02). After HBV-induced hepatocarcinogenesis in rats, the serum amino-acid profile is similar to that of liver cancer patients. In general, the increase in amino acid content in HCC tissues compared with non-cancer nodules suggests an increase in the amino acid pool in tumor cells. The protein synthesis in tumor cells of liver cancer patients is increased, and the amino acids in the serum are first consumed, such as methionine, phenylalanine and threonine.