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目的:研究妇血康颗粒促排卵作用。方法:40只未成年雌性Wistar大鼠随机均分为正常对照(等容生理盐水)组、己烯雌酚(1 mg/kg)组与妇血康高、低剂量(0.4、0.1 g/kg)组,灌胃给药,每天1次,连续14 d。末次给药1 h后,检测大鼠血清黄体生成素(LH)、孕激素(P)、雌二醇(E2)和促卵泡激素(FSH)的分泌量;计算大鼠卵泡数;对大鼠子宫、卵巢组织进行病理切片观察。结果:与正常对照组比较,妇血康高、低剂量组大鼠血清LH活性增强,P含量减少,卵泡成熟总数增加,大鼠卵巢组织状态明显改善,差异有统计学意义(P<0.05),且大鼠子宫变化不大;妇血康高剂量组大鼠血清E2含量减少,差异有统计学意义(P<0.05);妇血康低剂量组大鼠血清FSH含量减少,差异有统计学意义(P<0.05)。结论:妇血康颗粒可调节大鼠下丘脑-垂体-卵巢(HPO)轴的功能,促进卵泡发育成熟和排卵。
Objective: To study the ovulation promoting effect of Fuxuekang granules. Methods: Forty female Wistar rats were randomly divided into normal control (isoboric saline) group, diethylstilbestrol (1 mg / kg) group and Fuxugang high and low dose (0.4 and 0.1 g / kg) Gavage, 1 day, for 14 days. One hour after the last administration, the secretion of serum LH, P, E2 and FSH were measured; the number of follicles in rats was calculated; Uterus, ovarian tissue sections were observed. Results: Compared with the normal control group, the serum LH activity, P content and the total number of mature follicles increased significantly in the Xuexamphami and low-dose groups, and the ovarian tissue status in the rats was significantly improved (P <0.05) , And the uterus did not change much in the rats. The serum E2 level in the Fuxu Kang high dose group was decreased, the difference was statistically significant (P <0.05); FSH content in the Fuxukang low dose group was decreased, the difference was statistically Significance (P <0.05). Conclusion: Fuxuekang granule can regulate the function of hypothalamus-pituitary-ovary (HPO) axis in rats and promote follicular development and ovulation.