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目的对比观察新辅助化疗结合放疗与单纯放疗治疗局部晚期宫颈癌的疗效。方法选择2013年12月-2015年12月收治的局部晚期宫颈癌患者156例,根据随机数字表法分为观察组和对照组各78例,观察组采用新辅助化疗结合放疗进行治疗,对照组采用单纯放疗进行治疗,比较2组治疗效果及不良反应。结果观察组总缓解率为97.44%高于对照组的80.77%,差别有统计学意义(χ2=11.157,P<0.01)。2组不良反应发生率比较差异无统计学意义(P>0.05)。治疗前2组肿瘤直径比较差异无统计学意义(P>0.05);治疗后2组患者肿瘤直径均明显缩小,且观察组患者的肿瘤直径小于对照组,差异均有统计学意义(P<0.05)。结论新辅助化疗结合放疗治疗局部晚期宫颈癌临床效果明显,不良反应较少,具有临床推广价值。
Objective To compare the efficacy of neoadjuvant chemotherapy with radiotherapy and radiotherapy alone in the treatment of locally advanced cervical cancer. Methods 156 patients with locally advanced cervical cancer who were admitted from December 2013 to December 2015 were divided into observation group (78 cases) and control group (78 cases) according to the random number table. The patients in the observation group were treated with neoadjuvant chemotherapy combined with radiotherapy. The control group Treatment with radiotherapy alone, the two groups compared the efficacy and adverse reactions. Results The total remission rate of the observation group was 97.44% higher than that of the control group (80.77%), the difference was statistically significant (χ2 = 11.157, P <0.01). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). There was no significant difference in tumor diameter between the two groups before treatment (P> 0.05). After treatment, the diameter of tumor was significantly reduced in both groups, and the diameter of tumor in observation group was smaller than that in control group (P <0.05) ). Conclusion Neoadjuvant chemotherapy combined with radiotherapy for the treatment of locally advanced cervical cancer has obvious clinical effects, fewer adverse reactions, with clinical value.