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本文采用放射免疫分析方法测定不同频率电针引起大鼠脊髓液中血管紧张素Ⅱ(AⅡ)免疫活性(ir)的变化,并观察阿片受体在其中起的作用。结果表明:(1)2Hz电针时大鼠脊髓灌流液中AⅡ-ir减少20%,但无立计学意义;15Hi电针使灌流液中AⅡ-ir降低62%(P<0.01);100Hi时AⅡ-ir增加60%(P<0.05)。(2)脊髓蛛网膜下腔(i.t.)注射阿片受体桔抗剂纳洛酮后,15Hz电针反使灌流液中AⅡ含量增加125%(P<0.05)。(3)特异性μ受体激动剂ohmefentanyl可以抑制AⅡ释放,δ和K激动剂无效。(4)i.t.注射AⅡ受体拮抗剂saralasin明显加强100Hz电针镇痛(P<0.05),但对2Hz和15Hz电针针效影响不大。结果提示:AⅡ拮抗剂与电针合用可能有助于加强100Hz电针的镇痛效果。内源性阿片肽通过μ受体抑制电针期间AⅡ的释放。
In this paper, radioimmunoassay was used to determine the change of immunoreactivity (ir) of angiotensin Ⅱ (AⅡ) in rat spinal fluid induced by electroacupuncture at different frequencies and to observe the role of opioid receptors in it. The results showed that: (1) AII-ir decreased by 20% in rat spinal cord perfusate at 2 Hz electroacupuncture, ; AII-ir increased by 60% at 100Hi (P <0.05). (2) After intracerebral arachnoid (i.t.) injection of naloxone, an opiate receptor antagonist, the AII content in perfusate increased by 125% (P <0.05) by 15Hz electroacupuncture. (3) The specific mu receptor agonist ohmefentanyl can inhibit A Ⅱ release, δ and K agonists ineffective. (4) i. t. Injection of AII receptor antagonist saralasin significantly enhanced 100Hz electroacupuncture analgesia (P <0.05), but it did not affect acupuncture at 2Hz and 15Hz. The results suggest that: A Ⅱ antagonist combined with electroacupuncture may help to strengthen the analgesic effect of 100Hz EA. Endogenous opioid peptides inhibit the release of AII during electroacupuncture through the mu receptor.