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报告一种环激酶抑制剂p21~(WAFI/CIPI)在通过人参皂苷Rh2(G-Rh2)处理诱导的SK-HEP-1细胞凋亡的早期阶段经过蛋白酶解加工成为较小的片段p14的过程。酶解加工的过程是caspase-3激活的结果,并伴随细胞形态学和DNA裂解的早期变化。当与从G-Rh2处理的细胞获得的细胞提取物一起孵化时,迁移的p21~WAFI/CIPI)在体外被切割成一个p14片段。通过添加一种特殊的caspase-3抑制剂Ac-DEVD-CHO
Reported that a cyclokinase inhibitor p21~(WAFI/CIPI) was proteolytically processed into a smaller fragment p14 during the early stage of SK-HEP-1 cell apoptosis induced by ginsenoside Rh2 (G-Rh2) treatment. . The process of enzymatic processing is the result of caspase-3 activation, accompanied by early changes in cell morphology and DNA cleavage. When hatched with cell extracts obtained from G-Rh2 treated cells, the migrating p21~WAFI/CIPI) is cleaved in vitro to a p14 fragment. By adding a special caspase-3 inhibitor Ac-DEVD-CHO