论文部分内容阅读
目的:探讨慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)急性加重期和临床缓解期患者血清瘦素、白细胞介素-6(interleukin-6,IL-6)及白三烯B4(leukotriene B4,LTB4)含量变化,及COPD患者血清瘦素与IL-6、LTB4的相关性。方法:COPD急性加重期患者38例(COPDⅠ组)、COPD临床缓解期患者38例(COPDⅡ组),同期健康体检者36名(对照组),均采用放射免疫法测定血清瘦素含量,采用双抗夹心ELISA法测定IL-6和LTB4含量,并进行分析。结果:血清IL-6、LTB4和瘦素含量COPDⅠ组高于COPDⅡ组,COPDⅡ组高于对照组,差异均有统计学意义(P<0.05),COPDⅠ组与COPDⅡ组患者血清IL-6和LTB4含量均与瘦素呈正相关。结论:血清瘦素参与了COPD炎症过程,并与IL-6和LTB4呈正相关。
Objective: To investigate the changes of serum leptin, interleukin-6 (IL-6) and leukotriene B4 in patients with acute obstructive pulmonary disease (COPD) and clinical remission , LTB4) levels in patients with COPD and serum leptin and IL-6, LTB4 correlation. Methods: Serum leptin levels were measured by radioimmunoassay in 38 COPD patients (COPD group Ⅰ), 38 patients with COPD (COPD group) and 36 healthy controls (control group) Anti-sandwich ELISA method for the determination of IL-6 and LTB4 content, and analysis. Results: Serum levels of IL-6, LTB4 and leptin were higher in COPD group Ⅰ than those in COPD group Ⅱ and COPD Ⅱ group (P <0.05). The levels of IL-6 and LTB4 in patients with COPDⅠand COPDⅡ Content and leptin were positively correlated. CONCLUSION: Serum leptin participates in the COPD inflammatory process and is positively correlated with IL-6 and LTB4.