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目前有30余种药物用于艾滋病毒感染治疗。3种及以上抗病毒药物联合应用显著提高了抗反转录病毒治疗的疗效,但也存在多种药物相互作用。同时,艾滋病患者常因机会感染接受治疗,而抗感染药物,尤其是抗结核、抗真菌药物的使用会使药物相互作用更加复杂。药物相互作用可能导致治疗疗效下降和(或)增加不良反应风险。本文主要介绍抗反转录病毒治疗和机会感染治疗中的重要药物相互作用以及与此有关的配伍禁忌和剂量调整。
There are currently more than 30 drugs for the treatment of HIV infection. The combination of three or more antiviral drugs significantly improved the efficacy of antiretroviral therapy, but there are also a variety of drug interactions. At the same time, AIDS patients are often treated for opportunistic infections, and the use of anti-infectives, especially anti-TB and antifungal medications, can complicate drug interactions. Drug interactions may result in diminished therapeutic efficacy and / or increase the risk of adverse reactions. This article describes the major drug interactions in the treatment of anti-retroviral and opportunistic infections and the associated incompatibilities and dose adjustments.