西地那非是研究人员在研究治疗心血管疾病药物时无意中发现的一种可以治疗男性勃起功能障碍的药物,它的商业用名为Viagra,在中国大陆人们多俗称它为“伟哥”。由于西地那非适应症的特殊性,临床上要求其口服制剂应该具备较好的崩解性能和溶出性能。西地那非的水溶性较差,该药物多以西地那非枸橼酸盐为原料制备[1-2]。在一定温度条件下,药物的溶出度及溶出速率与其比表面积成正比[3]。因此,药物粒度的大小能够 Sildenafil is a researcher in the treatment of cardiovascular disease drugs accidentally discovered that a treatment of male erectile dysfunction drugs, its commercial name is Viagra, more commonly known in mainland China as “Viagra ”. Due to the particularity of sildenafil indications, clinically required oral formulations should have good disintegration and dissolution properties. Sildenafil water solubility is poor, the drug mostly sildenafil citrate as raw material [1-2]. Under certain temperature conditions, the drug dissolution rate and dissolution rate is proportional to the specific surface area [3]. Therefore, the size of the drug can be