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目的 分析宫颈癌组织染色体微卫星不稳定性与人乳头瘤病毒 (HPV)感染状态并探讨其与临床病理参数的关系。方法 2 0 0 1年 7月至 2 0 0 3年 1月中国医科大学第二临床学院及辽宁省肿瘤医院应用PCR 聚丙烯酰胺凝胶 硝酸银银染技术 ,检测 6 0例宫颈癌组织 3p染色体 3个位点微卫星不稳定性与HPV感染状态。结果 2 3例宫颈癌组织存在微卫星不稳定 (38 3% ) ,微卫星不稳定性与分期、组织学类型及病理分级有关 ,与HPV感染无关。结论 微卫星不稳定性是一个独立于HPV感染之外的因素 ,在宫颈癌尤其腺癌的发展过程中起重要作用 ,并与宫颈癌预后有关
Objective To analyze the status of chromosome microsatellite instability and human papillomavirus (HPV) infection in cervical cancer and to explore its relationship with clinicopathological parameters. Methods From July 2001 to January 2003, the Second Clinical College of China Medical University and Cancer Hospital of Liaoning Province used PCR polyacrylamide gel silver nitrate silver staining to detect the chromosome 3p in 60 cervical cancer tissues Microsatellite Instability and HPV Infection at 3 Sites. Results Microsatellite instability (38 3%) was found in 23 cases of cervical cancer. Microsatellite instability was related to staging, histological type and pathological grade, but not HPV infection. Conclusion Microsatellite instability is a factor independent of HPV infection and plays an important role in the development of cervical cancer, especially adenocarcinoma, and is associated with the prognosis of cervical cancer