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前文谈了肝脏与药物的关系,本文就肝功能不良时的药物应用问题作一简述.肝功能不良影响药物代谢的转化肝病影响药物代谢转化的因素主要系:①细胞色素 P_(450)含量减少,及药物代谢酶活性降低,使药物代谢率减少;②肝血流量减少,使药物清除率降低;③血浆结合蛋白减少,使游离的药物浓度增加;④门脉系统不同程度阻塞,影响药物的首过作用.将产生下述种种临床效应.影响药效的发挥肝病患者的腹水、胃肠充气、充血或水肿,致
The previous article about the relationship between the liver and the drug, this article on the application of drugs in liver dysfunction to make a brief introduction of liver dysfunction drug metabolism of liver disease affecting drug metabolism and conversion factors are: ① cytochrome P 450 content Reduce, and reduce the activity of drug metabolizing enzymes, the drug metabolism rate decreased; ② reduced hepatic blood flow, so that drug clearance decreased; ③ plasma-bound protein decreased, so that the concentration of free drugs increased; ④ portal vein obstruction of different degrees, the impact of drugs Will lead to the following various clinical effects.Effects on the efficacy of liver disease patients play ascites, gastrointestinal inflatable, congestion or edema caused by