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目的探讨老年人消化性溃疡并出血与幽门螺杆菌(H.pylori)感染的关系,为其预防和治疗提供可靠依据。方法回顾性分析2007-12-2009-12在首都医科大学宣武医院住院治疗的消化性溃疡并出血的老年患者、消化性溃疡无并发症的老年患者、慢性胃炎老年患者、中青年患者的病例资料,所有患者均经内镜检查确诊,并经病理学检查;同时行13C-尿素呼气试验和取病理组织切片行Warthin-starry银染色检查检测Hp感染情况。结果消化性溃疡并出血老年组36例中,Hp阳性13例,阳性率为36.1%,消化性溃疡老年组与出血老年组比较无统计学意义,但慢性胃炎老年患者组与出血老年组有统计学意义。中青年患者组Hp阳性率与出血老年组比较有明显统计学意义。结论老年人上消化道疾病伴Hp感染的疾病中慢性胃炎所占比例最高(58.5%),其次为消化性溃疡(46.4%),感染率相对较低的为消化性溃疡并出血(36.1%);且幽门螺杆菌的感染随年龄增长而降低。
Objective To investigate the relationship between peptic ulcer bleeding and H. pylori infection in the elderly and provide a reliable basis for its prevention and treatment. Methods A retrospective analysis was performed on the elderly patients with peptic ulcer and hemorrhage hospitalized at Xuanwu Hospital, Capital Medical University between December 2007 and December 2009, elderly patients without complications of peptic ulcer, elderly patients with chronic gastritis and young and middle-aged patients , All patients were diagnosed by endoscopy and pathological examination; simultaneous detection of Hp infection by 13C-urea breath test and pathological tissue sections Warthin-starry silver staining. Results Peptic ulcer and hemorrhage in the elderly group of 36 cases, Hp-positive in 13 cases, the positive rate was 36.1%, peptic ulcer elderly group and hemorrhagic elderly group was no statistical significance, but chronic gastritis elderly group and hemorrhage elderly group statistics Significance of learning. The positive rate of Hp in middle-aged and young patients was significantly higher than that in the elderly group. Conclusions Chronic gastritis is the highest proportion of upper gastrointestinal diseases (HH) infection in the elderly (58.5%), followed by peptic ulcer (46.4%) and peptic ulcer with hemorrhage (36.1%), ; And Helicobacter pylori infection decreased with age.