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根据自身免疫性甲状腺疾病（Ａｕｔｏｉｍｍｕｎｏｔｈｙｒｏｉｄｄｉｓｅａｓｅ，ＡＩＴＤ）发病机制新学说：独特型－抗独特型免疫网络学说，用兔抗人ＴＳＨ抗体在同种家兔中制备了ＴＳＨ抗独特型抗体（ＴＳＨＡｂ＿２），并从免疫学、生物学功能方面进行了鉴定，同时用豚鼠脂肪中ＴＳＨ受体纯化了ＴＳＨＡｂ＿２并检测了兔血清Ｔ＿４、ＴｍＡｂ的值，发现免疫后两者均明显升高（Ｐ＜０．０１）．本实验支持ＡＩＴＤ中独特型－抗独特型免疫网络学说。
According to the new theory of the pathogenesis of autoimmune thyroid disease (AITD): idiotype-anti-idiotypic immune network theory, TSH anti-idiotypic antibody (TSHAb_2) was prepared in rabbits with anti-human TSH antibody The immunological and biological functions were evaluated. At the same time TSHAb_2 was purified from TSH receptor of guinea pig fat and the serum T_4 and TmAb values were detected. The results showed that both of them were significantly increased after immunization (P <0.01) . This experiment supports AITD unique type - anti-idiotype immune network theory.