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目的 研究早期胃癌患者术前胃镜活检组织中血管内皮生长因子 (VEGF)、p5 3蛋白和增殖细胞核抗原 (PCNA)表达与胃癌预后的关系。方法 对 1980～ 1991年 6 8例早期胃癌患者的术前胃镜活检标本做VEGF、p5 3蛋白和PCNA免疫组化染色。结果 胃癌复发组的VEGF阳性率 (5 / 5 )显著高于无复发组 (14/ 6 3) ,P <0 0 1;VEGF阳性胃癌患者的 8年生存率 (14/ 19)显著低于VEGF阴性胃癌患者的生存率 (4 9/ 49) ,P <0 0 1;p5 3蛋白和PCNA表达在 2组中差异无显著意义 ,P >0 0 5。结论 胃镜活检组织中VEGF的表达对于早期胃癌患者是重要的预后因素 ,可指导术前术式的选择。
Objective To study the relationship between the expression of vascular endothelial growth factor (VEGF), p53 protein and proliferating cell nuclear antigen (PCNA) and the prognosis of gastric cancer. Methods VEGF, p53 protein and PCNA immunohistochemical staining were performed on preoperative gastroscope biopsies of 68 patients with early gastric cancer from 1980 to 1991. Results The positive rate of VEGF (5 / 5) in the recurrence group was significantly higher than that in the non-recurrence group (14 / 63), P <0 01. The 8-year survival rate of VEGF-positive gastric cancer was significantly lower than that of VEGF (14 / 19). The survival rate of negative gastric cancer patients (49/49), P <0 01; p53 protein and PCNA expression in the two groups showed no significant difference, P> 0 05. Conclusion The expression of VEGF in gastroscope biopsy is an important prognostic factor for patients with early gastric cancer. It can guide the choice of preoperative surgical methods.