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目的:探讨合并幽门螺杆菌感染消化性溃疡四联除菌的治疗,分析其临床疗效。方法:选取2011年5月~2013年5月在我院诊断为幽门螺杆菌感染消化性溃疡的145例患者为研究对象,进行回顾性分析。根据患者的病例资料,其中77例分为研究组,予“兰索拉唑+果胶铋+阿莫西林+甲硝唑”;另外68例分为对照组,予“兰索拉唑”。10周后,通过随访或患者复查的临床症状和辅助检查来判定疗效,统计分析患者所有的临床数据。结果:研究组总有效率与对照组总有效率比较(P<0.05),具有显著统计学意义;并且,两组中各自治愈人数、有效人数、无效人数间的差异(P<0.05),具有显著统计学意义。两组总不良反应率间的差异(P<0.05),具有显著统计学意义;两组中各自胃部不适、腹泻、乏力间的差异(P<0.05),具有显著统计学意义。结论:采用四联除菌治疗幽门螺杆菌感染消化性溃疡时,临床疗效显著,安全可靠,值得临床参考。
Objective: To explore the treatment of peptic ulcer combined with Helicobacter pylori quadruple sterilization, analyze its clinical efficacy. METHODS: A total of 145 patients with peptic ulcer disease diagnosed as Helicobacter pylori infection in our hospital from May 2011 to May 2013 were selected as the study subjects and analyzed retrospectively. According to the patient’s case data, 77 patients were divided into study group, given “Lansoprazole + pectin bismuth + amoxicillin + metronidazole ”; the other 68 cases were divided into control group, to Azole ". After 10 weeks, the clinical symptoms and auxiliary examinations were followed up or patient review to determine the efficacy of statistical analysis of all patients with clinical data. Results: The total effective rate in the study group was significantly higher than that in the control group (P <0.05), and there was significant difference between the two groups (P <0.05) Significant statistical significance. There was significant difference between the two groups (P <0.05). There was significant difference between the two groups in gastric discomfort, diarrhea and fatigue (P <0.05). Conclusion: The quadratic sterilization of Helicobacter pylori infection peptic ulcer, the clinical effect is significant, safe and reliable, it is worth clinical reference.