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目的探讨早期乳腺癌保乳手术术中电子线照射的可行性及近期效果。方法 36例早期乳腺癌患者接受保乳手术+术中放疗(A组),使用9Mev电子线21Gy一次照射;另41例患者接受术后全乳照射(B组),剂量为50～60Gy/5～6周(全乳50Gy,瘤床加量至60Gy),比较两组放疗时间及费用、毒副反应、美容效果、肿瘤复发事件、手术及伤口愈合时间等。结果与B组相比,A组放疗时间短[(3～5min×1次)vs.3～5min×(25～30)次)]、费用少[(3300±135)元vs.(13800±566)元]、形体满意度佳(97.2%vs.87.8%)、毒副反应少,而手术时间[(128±18)minvs.(94±12)min]和切口愈合时间[(13.8±2.4)dvs.(8.1±1.8)d]延长。结论保乳手术术中放疗具有省时、省钱、照射部位确切、美容效果佳、毒副反应小等特点。
Objective To investigate the feasibility and short-term effect of electron beam irradiation in breast conserving surgery during early breast cancer. Methods Thirty-six patients with early-stage breast cancer received operation of breast-conserving surgery and intra-operative radiotherapy (group A) with one dose of 21 Gy of 9Mev electron beam. The other 41 patients received whole-body irradiation (group B) at dose of 50-60 Gy / ~ 6 weeks (whole milk 50Gy, tumor bed dosage to 60Gy), compared the two groups of radiotherapy time and cost, toxicity, cosmetic effect, tumor recurrence, operation and wound healing time. Results Compared with group B, the time of radiotherapy in group A was shorter (3 to 5 min × 1 vs 3 to 5 min × (25 to 30) times), and the cost was less [(3300 ± 135) vs. (13800 ± (128 ± 18) minvs. (94 ± 12) min] and the healing time of incision [(13.8 ± 2.4) ) dvs. (8.1 ± 1.8) d]. Conclusion The operation of breast-conserving surgery with time-saving radiotherapy, save money, the exact site of exposure, good cosmetic results, small side effects.