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为寻求新的能有效保存体外循环中血小板数量和功能的药品,本实验观察了丹参酮Ⅱ～A磺酸钠在部分体外循环中对犬血小板的影响,实验表明此药能有效地抑制血小板的粘附功能,给药后血小板粘附率很快从接近50％降至5％左右,转流结束后血小板计数仍在原先的90％以上,光镜观察见用药组血小板数量多,体积较大,形态完好,颗粒丰富,无聚集现象,提示此药不仅抑制了血小板的粘附,且抑制了聚集,释放等反应。
In order to seek new drugs that can effectively preserve the quantity and function of platelets during cardiopulmonary bypass, this experiment observed the effect of tanshinone Ⅱ-A sulfonate on platelet in some CPB patients. The experiment shows that the drug can effectively inhibit platelet adhesion With the function, after administration of platelet adhesion rate quickly reduced from nearly 50% to 5%, platelet count after the end of the transfer is still above the original 90%, light microscopy to see the number of platelets in the treatment group, larger, Shape intact, abundant particles, no aggregation phenomenon, suggesting that the drug not only inhibited platelet adhesion, and inhibited the aggregation, release and other reactions.