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乳腺癌是全球女性最常见的恶性肿瘤之一,根据2008年GLOBOCAN统计,全球乳腺癌的发病率约38.9/10万,1989—2008年,乳腺癌的发病率更是位居中国城市女性恶性肿瘤发病率第一位并持续升高,目前认为乳腺癌的发生与遗传因素、体重、饮食、运动、重金属污染等危险因素相关,特别是与过多的雌激素暴露有密切关系~([1,2])。1雌激素受体雌激素受体(estrogen receptor,ER)属于甾体激素
Breast cancer is one of the most common malignant tumors in the world. According to GLOBOCAN in 2008, the incidence of breast cancer in the world is about 38.9 / 100000. The incidence of breast cancer in 1989-2008 was even higher among Chinese urban women with malignant tumors The incidence of the first and continued to rise, now that the occurrence of breast cancer and genetic factors, body weight, diet, exercise, heavy metal pollution and other risk factors, especially with excessive estrogen exposure are closely related ~ ([1, 2]). 1 estrogen receptor estrogen receptor (estrogen receptor, ER) belong to the steroid hormone