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目的研究血清脂联素(adiponectin)、瘦素(leptin)与白细胞介素(IL-1、6、8)水平变化在急性脑梗死的临床诊断、治疗、病情转归和判断预后的应用价值。方法以ELISA法分别检测急性脑梗死患者治疗前后以及正常对照组血清瘦素、脂联素及IL-1、IL-6、IL-8含量,并探讨各指标与神经功能缺损的关系。结果急性脑梗死患者治疗前后血清瘦素及IL-1、IL-6、IL-8含量较对照组明显升高(P<0.01),脑梗死治疗后以上各指标明显下降;而血清脂联素结果在治疗前较对照组明显降低(P<0.01),治疗后升高程度与治疗前及对照组差异具有统计学意义(P<0.01)。脑梗死组神经功能缺损程度与各指标变化均呈显著相关(P<0.01)。结论血清脂联素、瘦素及IL-1、IL-6、IL-8含量的变化与脑梗死的临床变化有较密切的关系,可以作为脑梗死病情变化的监测指标和预后判断指标,同时也为在脑梗死发病早期药物治疗开发提供临床实验依据。
Objective To investigate the clinical value of serum adiponectin, leptin and interleukin (IL-1, 6,8) levels in the diagnosis, treatment, prognosis and prognosis of acute cerebral infarction. Methods Serum leptin, adiponectin, IL-1, IL-6, IL-8 levels in patients with acute cerebral infarction before and after treatment and in normal control group were detected by ELISA respectively. The relationship between each index and neurological deficit was also explored. Results The levels of serum leptin, IL-1, IL-6 and IL-8 in patients with acute cerebral infarction were significantly higher than those in the control group (P <0.01) Results before treatment was significantly lower than the control group (P <0.01), after treatment, the level of increase and before treatment and control group difference was statistically significant (P <0.01). The degree of neurological deficit in cerebral infarction group was significantly correlated with the changes of each index (P <0.01). Conclusions The changes of serum adiponectin, leptin, IL-1, IL-6 and IL-8 levels are closely related to the clinical changes of cerebral infarction, which can be used as the monitoring indicators and prognostic indicators of the changes of cerebral infarction It also provides experimental basis for the development of drug therapy in the early stage of cerebral infarction.