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小鼠每日经口染毒直链烷基苯磺酸钠（ＬＡＳ）６４５、３２５ｍｇ／ｋｇ，同时设空白和阳性对照组。分别染毒一天和连续三及五天，用常规病理、电镜和酶组织化学技术进行观察。结果发现，ＬＡＳ实验组睾丸组织病理形态学改变随着染毒剂量和时间的增加而明显加重；生精细胞线粒体凝聚性空泡变性；ＳＤＨ、ＬＤＨ、ＡＣＰ酶活性显著下降。讨论了毒作用的可能机理并提出合理建议。
The mice were orally exposed to 645,325 mg / kg sodium lactic acid (LAS) daily, while blank and positive control groups were established. One day and three consecutive days and five days, respectively, with conventional pathology, electron microscopy and enzyme histochemical techniques were observed. The results showed that the histopathological changes of testis in LAS group significantly aggravated with dose and time; the mitochondrial cohesive vacuolar degeneration of spermatogenic cells; and the activity of SDH, LDH and ACP decreased significantly. Discusses the possible mechanisms of toxic effects and makes reasonable suggestions.