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目的探究血清人绒毛膜促性腺激素(β-h CG)、超敏C-反应蛋白(hs-CRP)和C-反应蛋白(CRP)水平预测胎膜早破孕妇宫内感染的价值。方法选取2012年12月-2014年12月该院妇产科收治的91例胎膜早破孕妇为观察组,另选取同期剖宫产分娩的95例孕妇为对照组,测定产前两组孕妇血清β-hCG、hs-CRP和CRP水平,采用ROC曲线分析其预测胎膜早破孕妇宫内感染的敏感性与特异性。结果观察组孕妇宫内感染率显著高于对照组,差异有统计学意义(P<0.05)。观察组孕妇血清β-hCG、hs-CRP和CRP水平显著高于对照组,差异有统计学意义(P<0.05)。观察组血清β-hCG、hs-CRP和CRP水平随着感染程度的加重而升高,差异有统计学意义(P<0.05)。根据ROC曲线分析发现,血清β-hCG、hs-CRP和CRP水平联合检测的灵敏性和特异性分别为91.98%和88.16%,显著高于单一指标,差异有统计学意义(P<0.05)。结论血清β-hCG、hs-CRP和CRP水平联合检测对于预测胎膜早破孕妇宫内感染,灵敏性高,特异性好,值得临床应用推广。
Objective To investigate the value of serum human chorionic gonadotropin (β-h CG), high-sensitivity C-reactive protein (hs-CRP) and C-reactive protein (CRP) in predicting intrauterine infection in premature rupture of membranes. Methods 91 cases of premature rupture of membranes treated by obstetrics and gynecology from December 2012 to December 2014 in our hospital were selected as the observation group. Another 95 pregnant women delivered by cesarean section at the same period were selected as the control group. Prenatal two groups of pregnant women Serum β-hCG, hs-CRP and CRP levels, the use of ROC curve analysis of the prognosis of premature rupture of membranes pregnant women with intrauterine infection sensitivity and specificity. Results The intrauterine infection rate of observation group was significantly higher than that of control group, the difference was statistically significant (P <0.05). The serum levels of β-hCG, hs-CRP and CRP in the observation group were significantly higher than those in the control group (P <0.05). The serum levels of β-hCG, hs-CRP and CRP in observation group increased with the severity of infection, the difference was statistically significant (P <0.05). According to the ROC curve analysis, the sensitivity and specificity of the combined detection of serum β-hCG, hs-CRP and CRP levels were 91.98% and 88.16%, respectively, which were significantly higher than those of single indicators (P <0.05). Conclusions The combined detection of serum β-hCG, hs-CRP and CRP level is of high sensitivity and specificity for predicting intrauterine infection of premature rupture of membranes. It is worthy of clinical application.