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目的 :观察可乐定贴片戒烟效果。方法 :自愿戒烟者 2 0人 ,随机、双盲分为 2组 ,每组各 10人。用药组于胸部贴可乐定贴片 2片 ( 2 .5mg/片 ) ,1wk更换 1次 ,连续 5wk ;安慰剂组 ,用空白贴片 ,其他完全相同。依据尿尼古丁代谢物 (可替宁 )及症状综合评价。结果 :2组吸烟量均显著减少 ,但可乐定贴片减轻焦虑、激惹等症状较明显。所用的可乐定剂量可使血压和心率稍有下降 ,但不影响继续用药。结论 :可乐定贴片可作为戒烟辅助药物
Objective: To observe the effects of clonidine patch smoking cessation. Methods: 20 voluntary smoking cessation patients were randomly divided into 2 groups with 10 patients in each group. The medication group in the chest with clonidine patch 2 (2.5mg / tablets), 1wk replacement 1, continuous 5wk; placebo group, with a blank patch, the other exactly the same. According to urine nicotine metabolites (cotinine) and symptoms of a comprehensive evaluation. Results: Two groups of smoking were significantly reduced, but the clonidine patch relieve anxiety, irritation and other symptoms more obvious. The dose of clonidine used will slightly lower blood pressure and heart rate, but does not affect the continued medication. Conclusion: Clonidine patch can be used as a smoking cessation drug