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自江崎(1957)和堀口等(1957)报告家族性链霉素中毒以来,据作者手头的文献已累计有34个家族92名患者(男38名,女54名),本文又报告3个家族。近年来人们对于链霉素中毒的遗传性问题颇为注目。一般认为,链霉素之所以能引起听力障碍在于它对内耳毛细胞的毒性,使毛细胞线粒体的电传导系统氧化、磷酸化障碍致ATP产生受阻。这种障碍有显著的个体差异,有的人用较少
Since the report of familial streptomycin poisoning by Ezaki (1957) and Horiguchi et al. (1957), according to the author’s literature, there are already 34 families and 92 patients (38 males and 54 females) in total. The paper also reports 3 families . In recent years, people are quite concerned about the genetic problem of streptomycin intoxication. Is generally believed that the reason why streptomycin can cause hearing impairment is that it is toxic to the hair cells of the inner ear, so that hair cells mitochondrial electrical conduction system oxidation, phosphorylation disorders caused by ATP blocked. This disorder has significant individual differences, while others use less