以3-羟基苯硼酸和取代含溴吡啶为原料,经Suzuki偶联和亲核取代两步反应合成了24个未见报道的含苯基吡啶基团的肟醚乙酸酯类化合物,其结构均通过1H NMR、ESI-MS和IR确证。初步生物活性测定结果表明,大部分目标化合物具有一定的抑菌活性,其中化合物5i、5r、5t在50 mg/L下对黄瓜霜霉病菌的抑制率达到80%。说明此类化合物具有作为杀菌剂先导进行进一步结构优化的潜力。 Twenty-four new oxime ether acetates containing phenylpyridine groups were synthesized by the Suzuki coupling and nucleophilic substitution reactions using 3-hydroxy-phenylboronic acid and substituted bromopyridine as starting materials. The structures of 1H NMR, ESI-MS and IR confirmed. The results of preliminary bioassay showed that most of the target compounds had some antibacterial activities. Compounds 5i, 5r and 5t inhibited the growth of cucumber downy mildew by 50% at 50 mg / L. Indicating that these compounds have the potential to be used as fungicide precursors for further structural optimization.