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目的：了解脊髓损伤（ＳＣＩ）后酸性成纤维细胞生长因子（ａＦＧＦ）的变化规律。方法：应用Ｓ－Ｐ免疫组化染色方法，观察ＳＣＩ前后脊髓中ａＦＧＦ的动态变化，并以图像分析技术对这种变化进行定量分析。结果：在正常脊髓中，ａＦＧＦ定位于前角运动神经元胞浆中；ＳＣＩ后ａＦＧＦ明显增高。结论：ＳＣＩ后，脊髓自身产生大量的ａＦＧＦ，这种自身保护机理可能在ＳＣＩ后的自身修复与再生方面起重要作用。
Objective: To investigate the changes of acidic fibroblast growth factor (aFGF) after spinal cord injury (SCI). Methods: The dynamic changes of aFGF in the spinal cord before and after SCI were observed by S-P immunohistochemical staining. Quantitative analysis of this change was performed by image analysis. Results: In normal spinal cord, aFGF localized in the cytoplasm of anterior horn motoneurons; aFGF increased significantly after SCI. Conclusion: After SCI, spinal cord itself produces a large amount of aFGF. This self-protection mechanism may play an important role in self-repair and regeneration after SCI.