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白细胞介素1受体相关激酶(IRAKs)作为TIR(Toll/IL-1 receptor)信号通路的重要连接体,在调节机体的自身免疫中起着重要的枢纽作用。家族成员包括IRAK-1、IRAK-2、IRAK-M、IRAK-4,其中IRAK-1和IRAK-4对信号传递起正性调节作用,IRAK-2和IRAK-M起负性调节作用。近年来,随着分子生物学和流行病学研究的不断深入,IRAKs基因多态性与炎症、免疫性疾病、肿瘤、代谢性疾病、心脑血管疾病、骨质疏松等疾病的关系逐步得到证实。
Interleukin-1 receptor-related kinases (IRAKs), as important linkers for the Toll / IL-1 receptor signaling pathway, play an important pivotal role in the regulation of autoimmunity in the body. Family members include IRAK-1, IRAK-2, IRAK-M, and IRAK-4. IRAK-1 and IRAK-4 play a positive role in signal transduction and IRAK-2 and IRAK-M play negative regulatory roles. In recent years, with the deepening of molecular biology and epidemiological studies, the relationship between IRAKs gene polymorphisms and diseases such as inflammation, immune diseases, tumors, metabolic diseases, cardiovascular and cerebrovascular diseases, osteoporosis has been gradually confirmed .