论文部分内容阅读
目的 : 了解 1%的喷昔洛韦霜在治疗单纯疱疹患者中的疗效及安全性。方法 : 采用多中心随机双盲法 ,并与 3%阿昔洛韦霜进行比较 ,患者外涂试验及对照药物 ,开始用药的前 12小时内 ,每 2小时一次 ,以后每天 5次 ,总疗程 5天。结果 : 疗后第 5天试验组痊愈率及总有效率分别为 6 5 .7% ( 6 9 10 5 )及 10 0 % ( 10 5 10 5 ) ,对照组的痊愈率及总有效率则分别为 4 6 .3% ( 5 0 10 8)及 90 .7% ( 98 10 8) ,二组间比较有高度显著性差异 (P =0 .0 0 4及P =0 .0 0 2 )。试验组及对照组的不良反应发生率分别为 13.3%及 11.1%。二组间比较无差异 (P =0 .6 2 )。结论 : 1%的PCV霜在治疗单纯疱疹中的疗效高于 3%的ACV霜 ,并可更快地促进皮损的愈合 ,且临床使用安全
Objective: To understand the efficacy and safety of 1% penciclovir cream in the treatment of patients with herpes simplex. METHODS: A multicenter randomized double-blind trial was conducted and compared with 3% acyclovir cream. Patients were topically tested with topical medications and were administered every 2 hours for the first 12 hours and 5 times daily thereafter. The total course of treatment 5 days. Results: On the fifth day after treatment, the cure rate and total effective rate of the experimental group were 65.7% (6 9 105) and 10 0% (10 5 105) respectively. The cure rate and total effective rate of the control group were respectively Were 43.3% (50.08%) and 90.7% (98.108), respectively. There was a highly significant difference between the two groups (P = .04 and P = .002). The incidence of adverse reactions in the experimental group and the control group were 13.3% and 11.1% respectively. There was no difference between the two groups (P = 0.62). Conclusions: The efficacy of 1% PCV cream in the treatment of herpes simplex is higher than that of 3% ACV cream and promotes the healing of the lesions more rapidly and is clinically safe to use