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目的 介绍玻璃酸及其衍生物的临床应用最新研究进展 ,为我国开展这方面的研究和开发新用途及新产品提供参考。方法 以近年发表的论文为素材 ,结合作者的实践经验 ,按玻璃酸在眼科方面的应用、治疗关节疾病、衍生物的制备及应用、玻璃酸及其衍生物的给药体系分别进行介绍 ,并对发展的方向进行了展望。结果与结论 玻璃酸及其衍生物在以上诸方面的应用取得了成功。衍生物具有理想的黏弹性和体内存留时间 ,效果更好。以玻璃酸及其衍生物构成的给药体系具有控释和定向给药的特点 ,具有广泛的开发前景
Objective To introduce the latest research progress of clinical application of hyaluronic acid and its derivatives, and to provide a reference for our country to carry out research in this field and develop new uses and new products. Methods Based on the papers published in recent years, combined with the author’s practical experience, the application of hyaluronic acid in ophthalmology, the treatment of joint diseases, the preparation and application of derivatives, the delivery system of hyaluronic acid and its derivatives were introduced respectively. The direction of development is prospected. Results and Conclusion The application of hyaluronic acid and its derivatives in the above aspects has achieved success. Derivatives have the ideal viscoelasticity and retention time in vivo, the effect is better. The delivery system composed of hyaluronic acid and its derivatives has the characteristics of controlled release and directional drug delivery and has extensive development prospect