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目的探讨妊娠期肝内胆汁淤积症(ICP)对妊娠结局及新生儿的影响。方法选取2013年5月-2017年4月本院妇产科诊治并分娩的ICP孕妇173例为ICP组,180例健康孕妇作为对照组,收集两组孕妇的年龄、孕次、产次,流产、早产、低出生体重儿、宫内窘迫、窒息等妊娠结局,新生儿血常规、凝血机制、肝功能等相关实验室指标及疾病情况,比较两组妊娠结局及新生儿实验室指标及疾病的差异。结果两组孕妇间年龄、孕次之间差异无统计学意义(P>0.05),但ICP组的产次、剖宫产数明显要高于对照组(P<0.05);两组新生儿出生时及出生后情况比较显示:ICP组低出生体重儿、羊水粪染、窒息、心肌损害的比例明显高于对照组(P<0.05);ICP组间新生儿总胆固醇(TC)、总胆汁酸(TBA)、碱性磷酸酶(ALP)明显高于对照组,差异有统计学意义(P<0.05)。结论 ICP可引起新生儿产时及产后异常,出现低出生体重儿、羊水粪染、窒息及新生儿ALP、TBA等实验室指标异常。
Objective To investigate the effect of intrahepatic cholestasis of pregnancy (ICP) on pregnancy outcomes and neonates. Methods From May 2013 to April 2017, 173 ICP pregnant women with obstetrics and gynecology were enrolled in the ICP group and 180 healthy pregnant women as the control group. The age, pregnancy time, delivery time and abortion of the two groups were collected , Preterm birth, low birth weight infants, intrauterine distress, suffocation and other pregnancy outcomes, neonatal blood, coagulation mechanisms, liver function and other laboratory indicators and disease conditions, pregnancy outcomes and neonatal laboratory indicators and disease difference. Results There was no significant difference in age and gestational age between the two groups of pregnant women (P> 0.05). However, the number of births and cesarean section in ICP group was significantly higher than that in control group (P <0.05) (P <0.05). Compared with control group, the total cholesterol (TC), total bile acid (TBA) and alkaline phosphatase (ALP) were significantly higher than those in the control group (P <0.05). Conclusion ICP can cause abnormalities of postpartum and postpartum neonates with abnormal laboratory indexes such as low birth weight, meconium amniotic fluid, asphyxia and neonatal ALP and TBA.