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目的探讨老年糖尿病肾病(DN)与血清单核细胞趋化蛋白-1(monocyte chemoattractant protein-1,MCP-1)、血清铁离子(SI)的相关性,为临床防治DN提供参考依据。方法将85例2型糖尿病患者根据24h尿白蛋白/肌酐比值(ACR)分为正常蛋白尿组(ACR<30μg/mg)28例、微量蛋白尿组(ACR 30~300μg/mg)29例及大量蛋白尿组(ACR>300μg/mg)28例,比较SI、MCP-1的变化,及其与ACR的相关性。结果大量蛋白尿组SI水平低于正常蛋白尿组和微量蛋白尿组,MCP-1水平高于正常蛋白尿组和微量蛋白尿组,差异均有统计学意义(P<0.05);SI与ACR呈负相关(r=-0.684,P<0.05),MCP-1与ACR呈正相关(r=0.871,P<0.05)。结论 SI和MCP-1随尿白蛋白排泄量增加而改变,SI和MCP-1可作为老年DN的早期诊断指标。
Objective To investigate the relationship between diabetic nephropathy (DN) and monocyte chemoattractant protein-1 (MCP-1) and serum ferric ion (SI) in elderly patients and to provide a reference for clinical prevention and treatment of DN. Methods Eighty-five patients with type 2 diabetes mellitus were divided into normal proteinuria group (ACR <30μg / mg), microalbuminuria group (ACR 30 ~ 300μg / mg) and urinary albumin / creatinine ratio A large number of albuminuria group (ACR> 300μg / mg) 28 cases, compared SI, MCP-1 changes, and its correlation with ACR. Results Compared with normal proteinuria group and microalbuminuria group, the level of SI in large proteinuria group was significantly higher than that in normal proteinuria group and microalbuminuria group (P <0.05). SI and ACR (R = -0.684, P <0.05). There was a positive correlation between MCP-1 and ACR (r = 0.871, P <0.05). Conclusions SI and MCP-1 may change with the increase of urinary albumin excretion. SI and MCP-1 may be used as early diagnosis indexes of elderly DN.