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对44例喉鳞癌组织分别进行了表皮生长因子(EGF)和c-erb B-2基因免疫组化研究。结果是:①EGF主要位于细胞浆内,c-erb B-2主要位于细胞膜;②EGF染色阳性为28例(63.6％),c-erb B-2染色阳性23例(52.3％);③EGF阳性率随病理学分级递增而增高;④c-erb B-2阴性病例的术后复发或死亡率为73.9％,而c-erb B-2阴性病例术后复发或死亡率为42.9％。提示,喉鳞癌细胞的分化程度与EGF表达密切相关;c-erb B-2阳性患者预后不良。
The immunohistochemical study of epidermal growth factor (EGF) and c-erb B-2 gene was performed in 44 cases of laryngeal squamous cell carcinoma. The results were: 1 EGF was mainly located in cytoplasm, c-erb B-2 was mainly located on the cell membrane; 2 EGF staining was positive in 28 cases (63.6%), c-erb B-2 was positive in 23 cases (52.3%); 3 EGF positive rate The pathological grades increased progressively and increased; 4c-erb B-2 negative cases had a postoperative recurrence or mortality of 73.9%, while c-erb B-2 negative cases had a postoperative recurrence or mortality of 42.9%. It is suggested that the degree of differentiation of laryngeal squamous cell carcinoma cells is closely related to the expression of EGF; patients with c-erb B-2 positive patients have a poor prognosis.